Else Kröner Forschungskolleg Cologne

Modern-day cancer therapy is witnessing a paradigmatic shift, away from globally toxic chemo- and radiotherapy, towards the use of non-genotoxic targeted small molecules and antibodies. These efforts are rooted in a steadily deepening molecular understanding of the patho-mechanisms underlying malignant transformation. The advent of modern technologies, particularly genome sequencing and novel approaches in high-performance computational biology, has revolutionized cancer research. These knowledge gains led to the development and clinical implementation of numerous novel drugs that specifically target genotype-stratified tumor entities. Prime examples are the use of specific tyrosine kinase inhibitors for EGFR-mutant-, EML4-ALK-rearranged- or ROS1-rearranged tumors, as well as BCR-ABL-fused leukemia.

These groundbreaking developments necessitate a profound change in the training and education of young oncologists. These physicians need solid clinical skills and a thorough training in molecular cancer research. Thus, we carefully assembled a peerless consortium of clinical opinion leaders and internationally competitive cancer researchers to create a structured training program for physician scientists that aim for a career in translational oncology.

Our consortium is tailored to address the question of clonal evolution and selection in response to targeted therapy. We consider this overarching question to be the major challenge in modern-day cancer therapy, as the majority of targeted approaches are eventually limited by the occurrence of acquired drug resistance. Our proposal is a cross-faculty joint effort of the members of the Center for Cancer and Immunology Research at the comprehensive cancer center of the University Cologne (CIO-CCIR) and also involves a non-university research center (Max-Planck-Institute for Metabolism Research). 

Events

9th Mildred Scheel Cancer Conference, May 15th-16th 2019

9th Cancer Conference by Deutsche Krebshilfe

20th International AEK Cancer Congress, Feburary 27th - March 1st 2019

Translating Cancer Biology: From Basic Mechanism to Therapeutic Exploitation

1st German Cancer Research Congress, February 4th–5th 2019

Scientific program and presentation of innovative research results

BIO.NRW.academy, January 31st 2019

Digitalisierung in den Life Sciences am Beispiel des Next Generation Sequencing

Seminar: Single cell genomics, January 17th 2019

Talk with Dennis Eastburn, San Francisco, CA

International Symposium on Hodgkin Lymphoma, October 27.-29., 2018

ISHL Cologne

Most recent advances in basic research, diagnosis and treatment of Hodgkin Lymphoma